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Tel Aviv University Using Nanotechnology to Treat Skin Cancer

Researchers at Tel Aviv University have designed a drug delivery system for the treatment of skin cancer melanoma that relies on nanotechnology, according to a university statement.

The "nanocarrier" is made up of biocompatible and biodegradable polymer, which is comprised of "repeating units of glutamic acids" (PGA - polyglutamic acid) and packages two different families of drugs together that have both been proven to be effective in the treatment of melanoma: BRAF inhibitors (Dabrafenib) and MEK inhibitors (Selumetinib).

"One of the major obstacles of the biological treatments is that after a while, the cancer cells develop resistance to the drugs," said leading researcher Prof. Ronit Satchi-Fainaro from the Department of Physiology and Pharmacology at the Sackler School of Medicine.

"We assume that by precise delivery of two or more targeted drugs that will attack the cancer cells forcefully and simultaneously from different directions, we can delay or even prevent the acquisition of this drug-resistance."

Their findings were published in the August 2020 issue of Advanced Therapeutics as the cover article. (JPost / VFI News)

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