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Tel Aviv

Breakthrough Israeli Study Finds a Potential Path to Reversing Hearing Loss

Researchers at Tel Aviv University's Gray Faculty of Medical and Health Sciences have identified a biological mechanism that could one day allow the regeneration of sensory hair cells in the inner ear, offering hope to millions who suffer from irreversible hearing loss. The process was long thought impossible in humans, since mammals cannot naturally regrow the cochlear hair cells that detect sound and convert it into signals for the brain. The study was led by Prof. Karen Avraham, dean of the faculty, and spearheaded by doctoral student Lama Khalaily, with the findings published in the journal Science Advances.

The team discovered a rare subset of supporting cells in the inner ear with unexpected regenerative potential, a kind of “reserve population” that everyone carries but that some people may possess in greater measure. By inhibiting the Notch signaling pathway, a key communication mechanism responsible for hair cell development, the researchers prompted these cells to begin converting into hair cells. Using live tissue imaging and single-cell analysis, the scientists traced how the cells entered a transitional state and started the regeneration process.

Avraham's laboratory has already identified 57 of the 224 genes worldwide known to be involved in hearing loss, and she called the work a proof of principle for a field still in its infancy. A future therapy could involve an injection into the inner ear, though the researchers cautioned that regulation and cost remain significant hurdles. The team said a deeper understanding of how certain cells regenerate may open the door to biological treatments that restore hearing rather than merely compensate for its loss.

(JPost/VFI News)

“Then the eyes of the blind shall be opened, and the ears of the deaf shall be unstopped.” – Isaiah 35:5