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Sheba Medical Center

In World 1st Bid to Cure Paralysis, Israeli Team Gears Up to Implant Innovative Spinal Cord

Israel is preparing to perform the world’s first spinal cord implant in a paralyzed patient in the coming weeks. Prof. Tal Dvir of Tel Aviv University said his team can engineer a spinal cord that functions like a natural one by implanting 3D-designed tissue into the damaged area, allowing fusion with healthy tissue above and below the injury.

The Health Ministry cleared compassionate-use trials in eight patients six months ago, and researchers are now selecting the first participant. Dvir said the technology was developed entirely in Israel and that it was always intended for the first surgery to take place with an Israeli patient.

Earlier preclinical work published in Advanced Science showed that 100% of recently paralyzed mice treated with the engineered implant walked again, and 80% of those with chronic paralysis regained mobility. The team’s biotech company, Matricelf, is advancing the platform with an eye toward broader clinical use.

Spinal cord injuries affect tens of millions worldwide, and neurons do not renew themselves, leaving patients with few options beyond stabilization. The engineered-tissue approach aims to overcome scarring and restore the broken “signal pathway” from brain to body.
(TOI/VFI News)