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Prof. Ayelet David’s lab team at Ben-Gurion University (from right to left): Valeria Feinstein, Nenad Milošević, Yvonne Ventura, Marie Rütter.

BGU Researchers Use Novel Chemo Delivery to Kill Colorectal Cancer Liver Metastases

A new study by a team of researchers at Ben-Gurion University of the Negev shows how they used a nanosized polymer to deliver a chemotherapy drug to safely and effectively eliminate colorectal cancer (CRC) metastases in the liver.

They also presented evidence of how they used a polymer, a large chain molecule, to minimize metastasis of melanoma to the lung. The peer-reviewed study, done on mice, was published during the previous month.

The study, led by PhD candidate Marie Rütter, demonstrated that delivering a small-molecule chemotherapy drug with the help of a larger-molecule polymer in a targeted way overcomes non-selective delivery and associated toxicity issues.

“We selected a strategy to kill or harm the blood vessels that supply oxygen and nutrients to the tumor rather than directly target the cancer cells themselves. It was a very efficient method because once we cut off the blood supply to the tumors, it translated to the deaths of hundreds of cancer cells,” she noted.

Half of the mice treated with the polymer went on to live the 100-day course of the experiment, appearing to have been cured of the cancer with no recurrence of the disease. The mice treated with the polymer also did much better than mice treated with conventional chemotherapy. (TOI / VFI News)

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