Spanish-Israeli Team Finds Mechanism to Make Blood Cancer Cells Harmless
New research led by scientists in Barcelona, Spain – with significant participation by colleagues at the Department of Human Genetics and Biochemistry of Tel Aviv University’s Sackler Faculty of Medicine: Prof. Gideon Rehavi, Nitzan Kol, Chen Avrahami, and Sharon Moshitch-Moshkovitz – has managed to do this. They have just published their findings in the high-impact journal Leukemia under the title, “Remodeling of the m6A RNA landscape in the conversion of acute lymphoblastic leukemia cells to macrophages.”
The article describes how leukemia cells become normal cells that no longer multiply by changing the chemical modifications – the so-called epigenetics – of a type of its genetic material called messenger RNA. The Spanish participants included Alberto Bueno-Costa, a researcher with the group of Dr. Manel Esteller, who heads the Josep Carreras Leukemia Research Institute at the University of Barcelona.
Experimental results showed that the reversal of the malignant cells into macrophages involved a tremendous revision in the chemical changes occurring on their messenger RNA – the carriers that help proteins form. The changes especially affected the distribution of an epigenetic mark named methylated adenine.
This change in the angle formed between two adjacent chemical bonds of these molecules causes instability of the proteins that define leukemia while favoring the appearance of microphages – proteins characteristic of the normal cells that are being born.
Although this line of research has not yet been tried on patients, the team said it seems quite promising and is worth further exploration as a new approach in the fight against leukemia. The more strategies developed to fight leukemia, the more hope there is for the half a million patients around the world who are diagnosed annually with blood malignancies. (JPost / VFI News)
Behold, I will bring to it health and healing, and I will heal them and reveal to them abundance of prosperity and security. - Jeremiah 33:6